Kratom tolerance is the number one impediment when looking to ensure peak medicinal effects. Here are some tricks one can use to keep tolerance low.

Strain Rotation

Strain rotation is a fantastic way to keep the medicinal effects of kratom fresh. When using a specific strain for a long period, you can develop a tolerance to its specific alkaloid profile; however, by switching strains daily, the alkaloid levels do not remain stable enough to develop a full tolerance to the effects.


  • Rotation by Effects– This method involves using alternating strains types (e.g. Mon. – Sedating, Tues. – Stimulating, Weds. – Sedating)
  • Rotation by Vein Color– Similar to the above method, this involves rotating by vein color (e.g. Mon. – Red, Tues. – White, Weds. – Green)

By using these methods, one can ensure that the alkaloid profiles are as varied as possible on consecutive days, which can keep tolerance at bay for a much longer period of time.

Note: Stem and vein kratom is often used as a substitute to further reduce tolerance, as its alkaloid profile is typically very different than the plain leaf.

However, because using this technique to its fullest requires 3-5+ different strains, this method of tolerance reduction, may not fit the means of everyone.


There are a variety of other ways to supplement tolerance reduction, including:

  • Magnesium - Magnesium supplementation is a great way to keep kratom tolerance low due to its NMDA antagonist effects, which are the primary opioid tolerance regulators. There are many studies supporting this, one of which can be found in April 1998’s publication of Anesthesia & Analgesia.
  • Exercise - Exercise is a very effective yet under rated method of reducing tolerance. Exercise’s reduction of tolerance is cumulative, meaning the more you exercise, and the more in shape you are, the less tolerance is developed, which potentiates the medicinal effects of kratom.